Thyroid nodules are increasingly prevalent. Although 85% to 95% of thyroid nodules are benign,6,7 thyroid cancer is the most common endocrine cancer and ranks as the ninth most common cancer in the United States.2
Palpable thyroid nodules occur in 5% to 7% of the adult population, but only 5% to 15% of those are diagnosed as thyroid cancer. Fine needle aspiration (FNA) is currently the standard preoperative diagnostic procedure used to evaluate thyroid nodules for cancer risk.
Cytologic examination results are often indeterminate
- Up to 35% of FNA biopsy results are indeterminate.3
- Among patients with cytologically indeterminate biopsies, the risk of malignancy can vary widely between institutions.3,8
- ~66% of nodules obtained from diagnostic surgery (hemithyroidectomy) are benign.9